All-weather road access is available year-round via the MacKenzie Highway. The MacKenzie Highway links to Highway 5 near Hay River, NT, providing access to the park and Fort Smith. Like many highways in the NT, Highway 5 is mostly hard-packed gravel. There is no all-weather road access to Fort Chipewyan.

Depending on conditions, a winter road may be open for approximately three months during the winter. This road connects Fort Smith with Fort Chipewyan and Fort McMurray in Alberta. Because of the large distances and potentially dangerous conditions, special precautions are needed for safe travel on the winter road.